Camilla BJÖRKEGREN - Tokyo College
Tokyo College Professor


Other affiliations Karolinska Institutet, Sweden Research Interest Chromosome organization, stability, and function Website Periods of stay March 1, 2023 - April 12, 2023
01 Description of research

Camilla Björkegren is Professor in cell and tumor biology at Karolinska Institutet, Stockholm, Sweden, where she is affiliated to two departments: Cell and Molecular Biology and Bioscience and Nutrition. Professor Björkegren focuses her research chromosome dynamics and genome stability, studying processes that are essential for life and prevent accumulation of disease-promoting chromosomal aberrations. With the aim to decipher molecular mechanisms that control these processes, professor Björkegren investigates the function of the evolutionary conserved family of SMC protein complexes (SMC: Structural Maintenance of Chromosomes) within cells and by diverse biochemical methods and techniques.

02 Publications and Other Research Activities

Note: Professor Björkegren was formerly known as Sjögren

Jeppsson K, Sakata T., Nakato R., Milanova S., Shirahige K., Björkegren C. Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks. Science Advances 2022; doi: 10.1126/sciadv.abn7063

Kanno T., Berta D., Sjögren C. The Smc5/6 complex is an ATP-dependent intermolecular DNA linker. Cell Reports, 2015, doi: 10.1016/j.celrep.2015.07.048.

Jeppsson K., Carlborg K., Nakato R., Berta D., Lilienthal I., Kanno T., Lindqvist A., Brink M., Dantuma N., Katou Y., Shirahige K., Sjögren C. The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement. PLoS Genetics, 2014; doi: 10.1371/journal.pgen.1004680.

Jeppsson K., Kanno T., Shirahige K., and Sjögren C. The maintenance of chromosome structure: positioning and function of SMC complexes. Invited review, Nat. Rev. Mol. Cell Biol. 2014; 15; 601-14

Kegel A., Betts-Lindroos H., Kanno K., Jeppsson K., Ström L., Katou Y., Itoh T., Shirahige K., Sjögren C. Chromosome length influences replication-induced topological stress. Nature, 2011; 471; 392-396.

Ström L., Karlsson C., Betts Lindroos H., Wedahl S., Katou Y., Shirahige K., Sjögren C. Post-replicative formation of cohesion is required for repair and induced by a single DNA break. Science, 2007; 317; 242-245.