NANGAKU Masaomi - Tokyo College


Other Affiliations Graduate School of Medicine, The University of Tokyo Research interests Nephrology
01 Description of Research

Masaomi Nangaku has performed studies to elucidate mechanisms of progression of kidney disease and to develop new treatments, especially from a point of view of oxygen biology. His research fields range from basic experiments to clinical trials, and he is involved in telemedicine.

02 Short Biography

1988 M.D., Faculty of Medicine, the University of Tokyo
1994 Visiting scientist, Division of Nephrology, University of Washington
1997 The Institute of Medical Sciences, Tokai University
1998 Division of Nephrology and Endocrinology/ Department of Hemodialysis and Apheresis, the University of Tokyo Hospital
2012 Professor, Division of Nephrology and Endocrinology, Graduate School of Medicine, the University of Tokyo
2014 Vice President, the University of Tokyo Hospital
2019 Vice Dean, Graduate School of Medicine, the University of Tokyo

03 Major Publications

1. Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, Ueda M, Fukui K, Shimizu A, Inagi R, Yamauchi T, Kadowaki T, Nangaku M. Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice. J Am Soc Nephrol 31, 560-577, 2020
2. Sugahara M, Tanaka T, Nangaku M. Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease. Kidney Int 92, 306-312, 2017
3. Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M. Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement. Sci Rep 5, 17838, 2015
4. Tanaka T, Nangaku M: Angiogenesis and hypoxia. Nature Rev Nephrol 9, 211-22, 2013
5. Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro JI, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y. Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A. Mol Cell Biol 32, 3018-32, 2012
6. Nangaku M: Chronic hypoxia and tubulointerstitial injury. A final common pathway to end stage renal failure. J Am Soc Nephrol 17, 17-25, 2006
7. Tanaka T, Miyata T, Inagi R, Fujita T, Nangaku M: Hypoxia in renal disease with proteinuria and/or glomerular hypertension. Am J Pathol 165, 1979-1992, 2004
8. Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishizaka N, Noiri E, Fujita T, Nangaku M: Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 14, 1825-32, 2003
9. Nangaku M, Pippin J, Couser WG: C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. J Am Soc Nephrol 13, 928-936, 2002
10. Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N: KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79, 1209-1220, 1994

04 Honors and Awards

1995 Medical Award, The University of Tokyo Medical Association
2002 Oshima Award, the Japanese Society of Nephrology
2004 Medical Research Encouragement Prize of The Japan Medical Association
2011 Best Staff Prize of the University of Tokyo Hospital
2015 Academic Award of the Japan Kidney Foundation
2020 Bälz Award