In 2016, he found the first sleep-promoting kinases, CaMKIIalpha and CaMKIIbeta and proposed the role of calcium and phosphorylation in sleep homeostasis. In 2018, he also found the first essential genes of REM sleep, muscarinic receptors M1 and M3. To accelerate these studies, he also invented whole-brain and whole-body clearing and imaging methods called CUBIC as well as the next-generation genetics (genetics without breeding) such as Triple-CRISPR and ES-mice methods for one-step production and analysis of KO and KI mice without crossing.
Work Experience
2024-present: Professor, Institute of Life Science, Kurume University
2023-present: Academic Visitor, The University of Oxford
2016-present: Affiliate Professor, Graduate School of IST, The University of Tokyo
2013-present: Professor, Graduate School of Medicine, The University of Tokyo
2011-2025: Laboratory Head, Laboratory for Synthetic Biology, RIKEN
2011-2025: Invited Professor, Graduate School of Frontier Biosciences, Osaka University
2017-2019: Principle Investigator, IRCN, The University of Tokyo
2012-2013: Visiting Professor, Graduate School of Medicine, The University of Tokyo
2006-2014: Invited Professor, Department of Biology, Osaka University
2004-2013: Laboratory Head, Functional Genomics Unit, RIKEN Center for Developmental 2003-2014: Laboratory Head, Laboratory for Systems Biology, RIKEN Center for Developmental Biology
Education
2000-2004: Department of Pharmacology, Graduate School of Medicine, The University of Tokyo
1994-2000: Faculty of Medicine, The University of Tokyo
Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles.
Wang Y, Cao S, Tone D, Fujishima H, Yamada RG, Ohno R, Shi S, Matsuzawa K, Yada S, Kaneko M, Sakamoto H, Onishi T, Ukai-Tadenuma M, Ukai H, Hanashima C, Hirose K, Kiyonari H, Sumiyama K, Ode KL, Ueda HR.
Nature 636, 412-421 (2024)
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.
Kon K, Ode KL, Mano T, Fujishima H, Takahashi RR, Tone D, Shimizu C, Shiono S, Yada S, Matsuzawa K, Yoshida SY, Yoshida Garçon J, Kaneko M, Shinohara Y, Yamada RG, Shi S, Miyamichi K, Sumiyama K, Kiyonari H, Susaki EA, Ueda HR.
Nat. Commun. 15, 6054 (2024)
Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep
Tone D, Ode KL, Zhang Q, Fujishima H, Yamada RG, Nagashima Y, Matsumoto K, Wen Z, Yoshida SY, Mitani TT, Arisato Y, Ohno RI, Ukai-Tadenuma M, Yoshida Garçon J, Kaneko M, Shi S, Ukai H, Miyamichi K, Okada T, Sumiyama K, Kiyonari H, Ueda HR.
PLOS Biol. 20, e3001813 (2022)
The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes
Katori M., Shi S., Ode K.L., Tomita Y., Ueda H.R.
Proc. Natl. Acad. Sci. U.S.A. 119, e2116729119 (2022)
Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep
Niwa Y., Kanda G.N., Yamada R.G., Shi S., Sunagawa G.A., Ukai-Tadenuma M., Fujishima H., Matsumoto N., Masumoto K., Nagano M., Kasukawa T., Galloway J., Perrin D., Shigeyoshi Y., Ukai H., Kiyonari H., Sumiyama K., Ueda H.R.
Cell Rep. 24, 2231-2247 (2018)
Knockout-rescue embryonic stem cell-derived mouse reveals circadian-period control by quality and quantity of CRY1
Ode K.L., Ukai H., Susaki E.A., Narumi R., Matsumoto K., Hara J., Koide N., Abe T., Kanemaki M.T., Kiyonari H., Ueda H.R.
Mol. Cell 65, 176-190 (2017)
Involvement of Ca2+-dependent hyperpolarization in sleep duration in mammals
Tatsuki F., Sunagawa G.A., Shi S., Susaki E.A., Yukinaga H., Perrin D., Sumiyama K., Ukai-Tadenuma M., Fujishima H., Ohno R., Tone D., Ode K.L., Matsumoto K., Ueda H.R.
Neuron 90, 70-85 (2016)
Whole-body imaging with single-cell resolution by tissue-decolorization
Tainaka K., Kubota S.I., Suyama T.Q., Susaki E.A., Perrin D., Ukai-Tadenuma M., Ukai H., Ueda H.R.
Cell 159, 911-924 (2014)
Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis
Susaki E.A., Tainaka K., Perrin D., Kishino F., Tawara T., Watanabe T.M., Yokoyama C., Onoe H., Eguchi M., Yamaguchi S., Abe T., Kiyonari H., Shimizu Y., Miyawaki A., Yokota H., Ueda H.R.
Cell 157, 726-739 (2014)
System-level identification of transcriptional circuits underlying mammalian circadian clocks
Ueda H.R., Hayashi S., Chen W., Sano M., Machida M., Shigeyoshi Y., Iino M., Hashimoto S.
Nat. Genet. 37, 187-192 (2005)
Setsurou Ebashi Prize (2023)
Ichimura Prize (2018)
Innovator of the Year (2017)
Yamazaki-Teiichi Prize (2015)
Tsukahara Nakaakira Memorial Award (2012)
Nagase Award (2011)
Changemaker of the year 2011 (2011)
JSPS Award (2010)
IBM Science Award (2009)
Japanese Society for Chronobiology Academic Encouragement Award (2007)
Genome Technology “Tomorrow’s PI”(2006)
MEXT Young Scientist Award (2006)
Tokyo Techno-Forum 21 Gold medal (2005)
Japan Innovator Award (2004)
Sleep Research Society/SRBR Joint Meeting Travel Award (2002)
Daigoro Moriwaki Award, Clear Thoughts Prize (2001)
